Article
A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma.
Oncotarget - 2 Aug 2016
Calabrese Francesco Maria, Clima Rosanna, Pignataro Piero, Lasorsa Vito Alessandro, Hogarty Michael D, Castellano Aurora, Conte Massimo, Tonini Gian Paolo, Iolascon Achille, Gasparre Giuseppe, Capasso Mario
Abstract excerpt
BACKGROUND: Neuroblastoma, a tumor of the developing sympathetic nervous system, is a common childhood neoplasm that is often lethal. Mitochondrial DNA (mtDNA) mutations have been found in most tumors including neuroblastoma. We extracted mtDNA data from a cohort of neuroblastoma samples that had undergone Whole Exome Sequencing (WES) and also used snap-frozen samples in which mtDNA was entirely sequenced by...
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