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Article

shaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores.

American journal of human genetics - 6 Jun 2024

Kelemen Martin, Vigorito Elena, Fachal Laura, Anderson Carl A, Wallace Chris

Abstract excerpt

We present shaPRS, a method that leverages widespread pleiotropy between traits or shared genetic effects across ancestries, to improve the accuracy of polygenic scores. The method uses genome-wide summary statistics from two diseases or ancestries to improve the genetic effect estimate and standard error at SNPs where there is homogeneity of effect between the two datasets. When there is significant evidence of...

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Identifiers

PMID: 38703768
DOI: 10.1016/j.ajhg.2024.04.009
PMCID: PMC11179256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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