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Article

SDPRX: A statistical method for cross-population prediction of complex traits.

American journal of human genetics - 5 Jan 2023

Zhou Geyu, Chen Tianqi, Zhao Hongyu

Abstract excerpt

Polygenic risk score (PRS) has demonstrated its great utility in biomedical research through identifying high-risk individuals for different diseases from their genotypes. However, the broader application of PRS to the general population is hindered by the limited transferability of PRS developed in Europeans to non-European populations. To improve PRS prediction accuracy in non-European populations, we develop a...

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Identifiers

PMID: 36460009
DOI: 10.1016/j.ajhg.2022.11.007
PMCID: PMC9892700

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