Article
The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.
EMBO reports - 1 May 2026
Wang Weina, Li Yue, Dong Sheng, Liu Yuwei, Guo Chenghang, Su Yuzhe, Tian Wei, Hu Xiaoyu, Wang Zhenshan
Abstract excerpt
Genome-wide association studies (GWASs) have identified hundreds of obesity-associated SNPs, but establishing their causality remains challenging. Here, we demonstrate that rs11676272, located in the ADCY3 gene, is a functional causal variant for obesity susceptibility. Bioinformatic analyses and dual-luciferase reporter assays indicate that the rs11676272 region may act as a human-gained enhancer regulating...
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