Article
Molecular and structural characterization of disease-associated APE1 polymorphisms.
DNA repair - 1 Jan 2000
Whitaker Amy M, Stark Wesley J, Flynn Tony S, Freudenthal Bret D
Abstract excerpt
Under conditions of oxidative stress, reactive oxygen species (ROS) continuously assault the structure of DNA resulting in oxidation and fragmentation of the nucleobases. When the nucleobase structure is altered, its base-pairing properties may also be altered, promoting mutations. Consequently, oxidative DNA damage is a major source of the mutation load that gives rise to numerous human maladies, including...
Topics
- Catalytic Domain
- Crystallography, X-Ray
- DNA
- DNA Damage
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Genetic Predisposition to Disease
- Humans
- Kinetics
- Mutation
- Neoplasms