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Article

Effects of Active Site Mutations on Specificity of Nucleobase Binding in Human DNA Polymerase η.

The journal of physical chemistry. B - 20 Apr 2017

Ucisik Melek N, Hammes-Schiffer Sharon

Abstract excerpt

Human DNA polymerase η (Pol η) plays a vital role in protection against skin cancer caused by damage from ultraviolet light. This enzyme rescues stalled replication forks at cyclobutane thymine-thymine dimers (TTDs) by inserting nucleotides opposite these DNA lesions. Residue R61 is conserved in the Pol η enzymes across species, but the corresponding residue, as well as its neighbor S62, is different in other...

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Identifiers

PMID: 28423907
DOI: 10.1021/acs.jpcb.6b09973
PMCID: PMC5402696

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