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A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity.

Journal of the American Chemical Society - 27 Apr 2011

Murphy Drew L, Jaeger Joachim, Sweasy Joann B

Abstract excerpt

DNA polymerase beta (pol beta) is the main polymerase involved in the base excision repair pathway responsible for repairing damaged bases in the DNA. Previous studies on the H285D mutant of pol beta suggested that the C-terminal region of the polymerase is important for polymerase function. In this study, the C-terminal region of pol beta was mutated to assess its role in polymerization. Kinetic experiments...

Topics

Base Sequence
Biocatalysis
Circular Dichroism
DNA
DNA Polymerase beta
Kinetics
Models, Molecular
Molecular Dynamics Simulation
Mutation

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Identifiers

PMID: 21452873
DOI: 10.1021/ja111099b
PMCID: PMC3601662

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