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Article

Activity of natural single nucleotide variants of human alkyladenine DNA glycosylase AAG R145H, G163S and R197C involved in DNA binding.

Biochimica et biophysica acta. Proteins and proteomics - 1 Nov 2026

Kladova O A, Tyugashev T E, Miroshnikov A A, Bakman A S, Kuznetsova A A

Abstract excerpt

Alkyladenine DNA glycosylase (AAG) is a critical enzyme in the base excision repair (BER) pathway that safeguards genome integrity by removing structurally diverse alkylated and deaminated purine lesions from DNA. It serves as a primary defense against alkylation-induced mutations, which are linked to cancer development, chronic inflammation, and neurodegenerative diseases. Single nucleotide variants (SNVs) in...

Read the complete abstract on PubMed

Topics

DNA Glycosylases
Humans
Polymorphism, Single Nucleotide
Molecular Dynamics Simulation
DNA
Excision Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Binding

Hypoxanthine

DNA Repair

Substrate Specificity

Adenosine

Adenine

Source

Identifiers

PMID: 42665032
DOI: 10.1016/j.bbapap.2026.141176

Provenance

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