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Article

Molecular dynamics simulations reveal R399Q mutation disrupts XRCC1-polβ interaction, potentially impairing DNA base excision repair pathway.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Goswami Nabajyoti, Dutta Rupam, Browne Rene Barbie, Borah Probodh, Mahanta Saurov, Medhi Subhash

Abstract excerpt

Mutations in XRCC1 can disrupt essential protein-protein interactions required for DNA base excision repair, potentially leading to genomic instability and increased cancer risk. This study employs large-scale molecular dynamics simulations to investigate the structural and functional consequences of the R399Q mutation on interactions with DNA ligase IIIα and DNA polymerase β. The results reveal that while the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40211828
DOI: 10.1080/07391102.2025.2481591

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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