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Article

Microglial function interacts with the environment to affect sex-specific depression risk.

Brain, behavior, and immunity - 1 Jul 2024

Fitzgerald Eamon, Pokhvisneva Irina, Patel Sachin, Yu Chan Shi, Peng Tan Ai, Chen Helen, Pelufo Silveira Patricia, Meaney Michael J

Abstract excerpt

There is a two-fold higher incidence of depression in females compared to men with recent studies suggesting a role for microglia in conferring this sex-dependent depression risk. In this study we investigated the nature of this relation. Using GWAS enrichment, gene-set enrichment analysis and Mendelian randomization, we found minimal evidence for a direct relation between genes functionally related to microglia...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38670238
DOI: 10.1016/j.bbi.2024.04.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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