Cell-type-specific genetic architecture of postpartum depression: A single-cell Mendelian randomization framework for causal gene discovery.

Abstract excerpt

BACKGROUND: Postpartum depression (PPD) is a severe psychiatric disorder with complex and multifactorial origins. Although genetic factors have been implicated, the cell-type-specific mechanisms linking genetic variation to disease susceptibility remain largely unexplored. METHODS: We conducted a transcriptome-wide Mendelian randomization (MR) analysis integrating bulk and single-nucleus brain eQTL data across...

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• Brain
• Depression, Postpartum
• Genome-Wide Association Study
• Mendelian Randomization Analysis
• Polypyrimidine Tract-Binding Protein