Article

Integrative Multi-Tissue Analysis Identifies Synaptic Gene Networks Specific to Major Depressive Disorder in Women

2026-08-27

Abstract excerpt

Major Depressive Disorder (MDD) shows marked gender differences in prevalence and molecular signatures. Transcriptomic studies of post-mortem human brain tissue have reported alterations in the expression of synapse-related genes in MDD, including gender-specific patterns. But it remains unclear whether transcriptional changes observed in the brains of women with MDD are detectable in peripheral blood and conserve...

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Literature Corpus work: 92f0e9e6-88da-5173-a851-fbcc6e53cb7c
DOI: 10.64898/2026.08.24.746654

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