Article

Function and constraint in enhancers with multiple evolutionary origins

2022-01-06

Abstract excerpt

<h4>Motivation</h4> Thousands of human gene regulatory enhancers are composed of sequences with multiple evolutionary origins. These evolutionarily “complex” enhancers consist of older “core” sequences and younger “derived” sequences. However, the functional relationship between the sequences of different evolutionary origins within complex enhancers is poorly understood. <h4>Results</h4> We evaluated the functi...

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Literature Corpus work: 60fee875-9f6f-5143-aeaa-a2eedff98ff9
DOI: 10.1101/2022.01.05.475150

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