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Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling

18 Apr 2024

Abstract excerpt

In vitro models of pediatric brain tumors (pBT) are instrumental for better understanding the mechanisms contributing to oncogenesis and testing new therapies; thus, ideally, they should recapitulate the original tumor. We applied DNA methylation (DNAm) and copy number variation (CNV) profiling to characterize 241 pBT samples, including 155 tumors and 86 pBT-derived cell cultures, considering serum vs serum-free...

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PMID: 38637626
DOI: 10.1038/s41698-024-00578-x

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