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3D patient-derived tumor models to recapitulate pediatric brain tumors In Vitro

2 Apr 2022

Abstract excerpt

Brain tumors are the leading cause of cancer-related deaths in children. Tailored therapies need preclinical brain tumor models representing a wide range of molecular subtypes. Here, we adapted a previously established brain tissue-model to fresh patient tumor cells with the goal of establishing3D in vitro culture conditions for each tumor type.Wereported our findings from 11 pediatric tumor cases, consisting of...

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PMID: 35381525
DOI: 10.1016/j.tranon.2022.101407

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