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Developmental origins and oncogenic pathways in malignant brain tumors

3 Apr 2019

Abstract excerpt

Brain tumors such as adult glioblastomas and pediatric high-grade gliomas or medulloblastomas are among the leading causes of cancer-related deaths, exhibiting poor prognoses with little improvement in outcomes in the past several decades. These tumors are heterogeneous and can be initiated from various neural cell types, contributing to therapy resistance. How such heterogeneity arises is linked to the tumor...

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PMID: 30945456
DOI: 10.1002/wdev.342

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