Article
Pediatric low-grade gliomas: molecular characterization of patient-derived cellular models.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Mar 2021
Chiacchiarini Martina, Besharat Zein Mersini, Carai Andrea, Miele Evelina, Del Baldo Giada, Mastronuzzi Angela, Catanzaro Giuseppina, Ferretti Elisabetta
Abstract excerpt
PURPOSE: Pediatric low-grade gliomas (pLGGs), the most frequent pediatric brain tumors, include different entities harboring distinct histological and molecular features. A major limitation in the development of treatments for these tumors is the absence of reliable in vitro models that would allow a better understanding of the molecular mechanisms that support their growth. Surgical excision is the primary...
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