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Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

15 Apr 2024

Abstract excerpt

Abstract Background Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role in liver I/R injury, however, it remains unclear whether this process is controlled or regulated by members of the DEAD/DExH-box helicase (DDX/DHX) family. Methods The expression of...

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PMID: 38622688
DOI: 10.1186/s40779-024-00524-9

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