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Article

Glutathione peroxidase 3 preserves hepatocyte mitochondrial quality control to enhance macrophage pro-regenerative phenotype during liver regeneration.

Clinical and translational medicine - 1 Jun 2026

Wang Yuechen, Xu Jian, Zhu Zeyu, Zhang Ye, Hu Haoran, Gao Yiyun, Tao Yuting, Yao Feifan, Zhou Suiqing, Zhong Weizhe, Rao Zhuqing, Zhou Haoming, Wang Xuehao

Abstract excerpt

BACKGROUND: Precise regulation of mitochondrial function is critical for liver regeneration. However, the underlying regulatory mechanism remains elusive. Here, we aimed to investigate the role of hepatocellular glutathione peroxidase 3 (GPX3) in liver regeneration. METHODS: In a 70% partial hepatectomy (PH) mouse model, immunostaining and single-cell RNA sequencing revealed significant enrichment but...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42216503
DOI: 10.1002/ctm2.70695
PMCID: PMC13240042

Genes

GPX3
VDAC1
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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