Article

RNA helicase DDX5 mediates adaptive response to multi-kinase inhibitors in liver cancer

2022-04-01

Abstract excerpt

<h4>Objective: </h4> To determine the role of RNA helicase DDX5 in sorafenib/multi-tyrosine kinase inhibitor (mTKI) response. Sorafenib and mTKIs downregulate DDX5 in vitro and preclinical hepatocellular carcinoma (HCC) models. In turn, sorafenib-mediated DDX5 downregulation activates Wnt/β-catenin and non-canonical NF-κB signaling, resulting in ferroptosis escape and mTKI resistance. Design and Results: Molecular...

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Literature Corpus work: a5f94e72-aee7-52df-9842-fa4272c46f4f
DOI: 10.1101/2022.03.31.486452

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