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The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

23 Jun 2020

Abstract excerpt

Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms are not fully understood. In the current study, we reported that the BRD7-P53-SLC25A28 axis played a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis inducers, bromodomain-containing protein 7 (BRD7) protein expression was remarkably increased through the...

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PMID: 32863216
DOI: 10.1016/j.redox.2020.101619

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