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The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease

1 Mar 2024

Abstract excerpt

BACKGROUND: Dachshund homolog 1 (DACH1) is widely acknowledged for its involvement in regulating diverse cell fates, but its precise regulatory mechanism in ferroptosis remains elusive. In this study, we investigated whether DACH1 modulates ferroptosis through affecting P53/solute carrier family 25 member 37 (SLC25A37) signaling in hepatic fibrogenesis. METHODS: CRISPR-Cas9 system was used to knockout DACH1 in...

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PMID: 38437058
DOI: 10.1097/hc9.0000000000000396

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