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Modulating G6PD/PGD to overcome FSP1/DHODH‐mediated ferroptosis defence: A novel oridonin derivative suppresses liver cancer

27 Aug 2025

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC), a globally prevalent malignancy with high mortality rates, presents an unmet need for innovative effective therapies. PURPOSE: This study aimed to explore the antitumour potential of compound XD, a novel oridonin derivative, on HCC and its underlying mechanism. EXPERIMENTAL APPROACH: The antitumour effects of compound XD were investigated in several HCC cells lines and...

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PMID: 40859915
DOI: 10.1111/bph.70160

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