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Identification of New Pathogenic Variants of Hereditary Diffuse Gastric Cancer.

Cancer research and treatment - 1 Oct 2024

Oh Seung-Young, Jang Giyong, Kim Jaeryuk, Jeong Kyoung-Yun, Kim Hyun Myong, Kwak Yoon Jin, Kong Seong-Ho, Park Do Joong, Lee Hyuk-Joon, Cho Sung-Yup, Kim Jong-Il, Yang Han-Kwang

Abstract excerpt

PURPOSE: Hereditary diffuse gastric cancer (HDGC) presents a significant genetic predisposition, notably linked to mutations in the CDH1 and CTNNA1. However, the genetic basis for over half of HDGC cases remains unidentified. The aim of this study is to identify novel pathogenic variants in HDGC and evaluate their protein expression. MATERIALS AND METHODS: Among 20 qualifying families, two were selected based on...

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Identifiers

PMID: 38605661
DOI: 10.4143/crt.2024.328
PMCID: PMC11491241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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