Article
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
Nature genetics - 1 Jun 2014
Wang Kai, Yuen Siu Tsan, Xu Jiangchun, Lee Siu Po, Yan Helen H N, Shi Stephanie T, Siu Hoi Cheong, Deng Shibing, Chu Kent Man, Law Simon, Chan Kok Hoe, Chan Annie S Y, Tsui Wai Yin, Ho Siu Lun, Chan Anthony K W, Man Jonathan L K, Foglizzo Valentina, Ng Man Kin, Chan April S, Ching Yick Pang, Cheng Grace H W, Xie Tao, Fernandez Julio, Li Vivian S W, Clevers Hans, Rejto Paul A, Mao Mao, Leung Suet Yi
Abstract excerpt
Gastric cancer is a heterogeneous disease with diverse molecular and histological subtypes. We performed whole-genome sequencing in 100 tumor-normal pairs, along with DNA copy number, gene expression and methylation profiling, for integrative genomic analysis. We found subtype-specific genetic and epigenetic perturbations and unique mutational signatures. We identified previously known (TP53, ARID1A and CDH1) and...
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