Article
Mapping the genetic landscape of hereditary diffuse-type gastric cancer progression.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 May 2026
Kemp Lars J S, van Cruchten Remco, Lomans Robin, Rutgers Natasja, Brosens Lodewijk A A, Kodach Liudmila L, van Dieren Jolanda M, Bisseling Tanya M, de Voer Richarda, Gloerich Martijn, van der Post Chella R S
Abstract excerpt
BACKGROUND: Hereditary diffuse gastric cancer (HDGC), caused by pathogenic variants (PVs) in CDH1, typically presents as early-stage mucosal lesions composed of non-proliferative signet ring cells (SRCs). While loss of E-cadherin initiates tumorigenesis, the somatic genetic alterations driving progression to advanced disease remain poorly understood. OBJECTIVE: Our goal was to identify morphological and genetic...
Topics
- Humans
- Stomach Neoplasms
- Disease Progression
- Female
- Cadherins
- Mutation
- Antigens, CD
- Male
- Exome Sequencing
- DNA Copy Number Variations