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Article

Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer.

Pharmacological reports : PR - 1 Jun 2024

Voutsadakis Ioannis A

Abstract excerpt

BACKGROUND: Genetic alterations are well characterized as contributors to the pathogenesis of cancers. Epigenetic abnormalities can lead to perturbations of the expression of genes in cancer cells without structural defects. Deregulation of proteins of the transcription machinery may result in perturbations of target genes. Mediator, a multiprotein component of the transcription machinery facilitates the function...

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PMID: 38602606
DOI: 10.1007/s43440-024-00589-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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