Article
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.
British journal of cancer - 6 Nov 2012
Kämpjärvi K, Mäkinen N, Kilpivaara O, Arola J, Heinonen H-R, Böhm J, Abdel-Wahab O, Lehtonen H J, Pelttari L M, Mehine M, Schrewe H, Nevanlinna H, Levine R L, Hokland P, Böhling T, Mecklin J-P, Bützow R, Aaltonen L A, Vahteristo P
Abstract excerpt
BACKGROUND: Mediator complex participates in transcriptional regulation by connecting regulatory DNA sequences to the RNA polymerase II initiation complex. Recently, we discovered through exome sequencing that as many as 70% of uterine leiomyomas harbour specific mutations in exon 2 of mediator complex subunit 12 (MED12). In this work, we examined the role of MED12 exon 2 mutations in other tumour types. METHODS:...
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