Article
Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.
The Prostate - 1 Jan 2016
Kämpjärvi Kati, Kim Nam Hee, Keskitalo Salla, Clark Alison D, von Nandelstadh Pernilla, Turunen Mikko, Heikkinen Tuomas, Park Min Ju, Mäkinen Netta, Kivinummi Kati, Lintula Susanna, Hotakainen Kristina, Nevanlinna Heli, Hokland Peter, Böhling Tom, Bützow Ralf, Böhm Jan, Mecklin Jukka-Pekka, Järvinen Heikki, Kontro Mika, Visakorpi Tapio, Taipale Jussi, Varjosalo Markku, Boyer Thomas G, Vahteristo Pia
Abstract excerpt
BACKGROUND: Mediator is a multiprotein interface between eukaryotic gene-specific transcription factors and RNA polymerase II. Mutations in exon 2 of the gene encoding MED12, a key subunit of the regulatory kinase module in Mediator, are extremely frequent in uterine leiomyomas, breast fibroadenomas, and phyllodes tumors. These mutations disrupt kinase module interactions and lead to diminished...
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