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Identifying Cancers Impacted by CDK8/19

3 Aug 2019

Abstract excerpt

CDK8 and CDK19 Mediator kinases are transcriptional co-regulators implicated in several types of cancer. Small-molecule CDK8/19 inhibitors have recently entered or are entering clinical trials, starting with breast cancer and acute myeloid leukemia (AML). To identify other cancers where these novel drugs may provide benefit, we queried genomic and transcriptomic databases for potential impact of CDK8, CDK19, or...

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PMID: 31382571
DOI: 10.3390/cells8080821

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