Article
Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations.
Breast cancer research : BCR - 25 May 2023
Miyashita Minoru, Bell Joshua S K, Wenric Stephane, Karaesmen Ezgi, Rhead Brooke, Kase Matthew, Kaneva Kristiyana, De La Vega Francisco M, Zheng Yonglan, Yoshimatsu Toshio F, Khramtsova Galina, Liu Fang, Zhao Fangyuan, Howard Frederick M, Nanda Rita, Beaubier Nike, White Kevin P, Huo Dezheng, Olopade Olufunmilayo I
Abstract excerpt
BACKGROUND: Endocrine-resistant HR+/HER2- breast cancer (BC) and triple-negative BC (TNBC) are of interest for molecularly informed treatment due to their aggressive natures and limited treatment profiles. Patients of African Ancestry (AA) experience higher rates of TNBC and mortality than European Ancestry (EA) patients, despite lower overall BC incidence. Here, we compare the molecular landscapes of AA and EA...
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