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Article

The molecular diversity of Luminal A breast tumors.

Breast cancer research and treatment - 1 Oct 2013

Ciriello Giovanni, Sinha Rileen, Hoadley Katherine A, Jacobsen Anders S, Reva Boris, Perou Charles M, Sander Chris, Schultz Nikolaus

Abstract excerpt

Breast cancer is a collection of diseases with distinct molecular traits, prognosis, and therapeutic options. Luminal A breast cancer is the most heterogeneous, both molecularly and clinically. Using genomic data from over 1,000 Luminal A tumors from multiple studies, we analyzed the copy number and mutational landscape of this tumor subtype. This integrated analysis revealed four major subtypes defined by...

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PMID: 24096568
DOI: 10.1007/s10549-013-2699-3
PMCID: PMC3824397

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