Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas.

Diabetes - 1 Jan 2021

Li Josephine H, Szczerbinski Lukasz, Dawed Adem Y, Kaur Varinderpal, Todd Jennifer N, Pearson Ewan R, Florez Jose C

Abstract excerpt

There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to antidiabetic medications. Polygenic scores provide increasing power to detect patterns of disease predisposition that might benefit from a targeted pharmacologic intervention. In the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Glycated Hemoglobin

Share to Hypoglycemic Agents

Share to Pharmacogenetics

Share to Sulfonylurea Compounds

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 33106254
DOI: 10.2337/db20-0530
PMCID: PMC7881853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas.PMID 33106254Read ↗

A Polygenic Score for Type 2 Diabetes Improves Risk Stratification Beyond Current Clinical Screening Factors in an Ancestrally Diverse SampleSemantic proximity Read ↗

The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.Semantic proximity Read ↗

Updated genetic score based on 34 confirmed type 2 diabetes Loci is associated with diabetes incidence and regression to normoglycemia in the diabetes prevention program.Semantic proximity Read ↗

Genome-wide association analysis identifies ancestry-specific genetic variation associated with medication response in the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)Semantic proximity Read ↗

Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older.Semantic proximity Read ↗

Polygenic Scores for Longitudinal Prediction of Incident Type 2 Diabetes in an Ancestrally and Medically Diverse Primary Care NetworkSemantic proximity Read ↗

Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.Semantic proximity Read ↗

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.Semantic proximity Read ↗

Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to SulfonylureasSemantic proximity Read ↗

Polygenic risk scores predict diabetic complications and their response to therapySemantic proximity Read ↗

Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicineSemantic proximity Read ↗

Polygenic subtype identified in ACCORD trial displays a favorable type 2 diabetes phenotype in the UKBiobank population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.