Article
Identification of Genetic Variation Influencing Metformin Response in a Multiancestry Genome-Wide Association Study in the Diabetes Prevention Program (DPP).
Diabetes - 1 Aug 2023
Li Josephine H, Perry James A, Jablonski Kathleen A, Srinivasan Shylaja, Chen Ling, Todd Jennifer N, Harden Maegan, Mercader Josep M, Pan Qing, Dawed Adem Y, Yee Sook Wah, Pearson Ewan R, Giacomini Kathleen M, Giri Ayush, Hung Adriana M, Xiao Shujie, Williams L Keoki, Franks Paul W, Hanson Robert L, Kahn Steven E, Knowler William C, Pollin Toni I, Florez Jose C
Abstract excerpt
Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not been replicated in the Diabetes Prevention Program (DPP). To assess pharmacogenetic interactions in prediabetes, we conducted a genome-wide association study (GWAS) in the DPP. Cox proportional hazards models tested associations with diabetes incidence in the metformin (MET; n = 876) and placebo (PBO; n = 887) arms....
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