Article
The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes.
PloS one - 1 Jan 2015
Walford Geoffrey A, Colomo Natalia, Todd Jennifer N, Billings Liana K, Fernandez Marlene, Chamarthi Bindu, Warner A Sofia, Davis Jaclyn, Littleton Katherine R, Hernandez Alicia M, Fanelli Rebecca R, Lanier Amelia, Barbato Corinne, Ackerman Rachel J, Khan Sabina Q, Bui Rosa, Garber Laurel, Stolerman Elliot S, Moore Allan F, Huang Chunmei, Kaur Varinderpal, Harden Maegan, Taylor Andrew, Chen Ling, Manning Alisa K, Huang Paul, Wexler Deborah, McCarthy Rita M, Lo Janet, Thomas Melissa K, Grant Richard W, Goldfine Allison, Hudson Margo S, Florez Jose C
Abstract excerpt
OBJECTIVE: Genome-wide association studies have uncovered a large number of genetic variants associated with type 2 diabetes or related phenotypes. In many cases the causal gene or polymorphism has not been identified, and its impact on response to anti-hyperglycemic medications is unknown. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH, NCT01762046) is...
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