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Exploring evolutionary trajectories in ovarian cancer patients by longitudinal analysis of ctDNA.

Clinical chemistry and laboratory medicine - 25 Sept 2024

Kutz Oliver, Drukewitz Stephan, Krüger Alexander, Aust Daniela, William Doreen, Oster Sandra, Schröck Evelin, Baretton Gustavo, Link Theresa, Wimberger Pauline, Kuhlmann Jan Dominik

Abstract excerpt

OBJECTIVES: We analysed whether temporal heterogeneity of ctDNA encodes evolutionary patterns in ovarian cancer. METHODS: Targeted sequencing of 275 cancer-associated genes was performed in a primary tumor biopsy and in ctDNA of six longitudinal plasma samples from 15 patients, using the Illumina platform. RESULTS: While there was low overall concordance between the mutational spectrum of the primary tumor...

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Identifiers

PMID: 38577791
DOI: 10.1515/cclm-2023-1266

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TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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