Article

Detecting repeated cancer evolution in human tumours from multi-region sequencing data

2017-06-27

Abstract excerpt

Carcinogenesis is an evolutionary process driven by the accumulation of genomic aberrations. Recurrent sequences of genomic changes, both between and within patients, reflect repeated evolution that is valuable for anticipating cancer progression. Multi-region sequencing and phylogenetic analysis allow inference of the partial temporal order of genomic changes within a patient’s tumour. However, the inherent stoch...

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Identifiers and source

Literature Corpus work: a03198ea-19ad-5b8f-bb76-74c4e91fba51
DOI: 10.1101/156729

Open publication

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