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Article

Clonal evolution of high-grade serous ovarian carcinoma from primary to recurrent disease.

The Journal of pathology - 1 Mar 2013

Castellarin Mauro, Milne Katy, Zeng Thomas, Tse Kane, Mayo Michael, Zhao Yongjun, Webb John R, Watson Peter H, Nelson Brad H, Holt Robert A

Abstract excerpt

High-grade serous carcinoma (HGSC) is the most common and fatal form of ovarian cancer. While most tumours are highly sensitive to cytoreductive surgery and platinum- and taxane-based chemotherapy, the majority of patients experience recurrence of treatment-resistant tumours. The clonal origin and mutational adaptations associated with recurrent disease are poorly understood. We performed whole exome sequencing...

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Identifiers

PMID: 22996961
DOI: 10.1002/path.4105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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