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Article

How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex.

Cell reports - 23 Apr 2024

Jones Alexander C, Wu Jian, Taylor Susan S

Abstract excerpt

Fatalska et al.1 use an interdisciplinary strategy to elucidate how an intrinsically disordered regulatory subunit of protein phosphatase 1 binds trimeric eIF2 and positions the phosphatase-substrate complex for dephosphorylation. As validation, they show that a disease mutation abolishes the interaction.

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Identifiers

PMID: 38573854
DOI: 10.1016/j.celrep.2024.114011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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