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Article

IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism.

Nature communications - 20 Oct 2024

Hornegger Harald, Anisimova Aleksandra S, Muratovic Adnan, Bourgeois Benjamin, Spinetti Elena, Niedermoser Isabell, Covino Roberto, Madl Tobias, Karagöz G Elif

Abstract excerpt

The insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a conserved RNA-binding protein that regulates RNA stability, localization and translation. IGF2BP1 is part of various ribonucleoprotein (RNP) condensates. However, the mechanism that regulates its assembly into condensates remains unknown. By using proteomics, we demonstrate that phosphorylation of IGF2BP1 at S181 in a disordered linker is...

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PMID: 39426983
DOI: 10.1038/s41467-024-53400-4
PMCID: PMC11490574

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