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Article

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2017

Kulkarni Prakash, Jolly Mohit Kumar, Jia Dongya, Mooney Steven M, Bhargava Ajay, Kagohara Luciane T, Chen Yihong, Hao Pengyu, He Yanan, Veltri Robert W, Grishaev Alexander, Weninger Keith, Levine Herbert, Orban John

Abstract excerpt

Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate-Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of the Activator Protein-1 (AP-1) transcription factor. Homeodomain-Interacting Protein Kinase 1 (HIPK1) phosphorylates PAGE4 at S9 and T51, but only T51 is critical...

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Share to Antigens, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28289210
DOI: 10.1073/pnas.1700082114
PMCID: PMC5380051

Genes

PAGE4
CLK2
HIPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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