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Article

Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility.

Scientific reports - 1 Jan 2013

Malaney Prerna, Pathak Ravi Ramesh, Xue Bin, Uversky Vladimir N, Davé Vrushank

Abstract excerpt

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by which its intrinsically disordered region (IDR) at the carboxyl-terminus (C-tail) executes its functions....

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Source

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Identifiers

PMID: 23783762
DOI: 10.1038/srep02035
PMCID: PMC3687229

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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