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Article

Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degeneration

1 Apr 2024

Abstract excerpt

The complex metabolic relationship between the retinal pigment epithelium (RPE) and photoreceptors is essential for maintaining retinal health. Recent evidence indicates the RPE acts as an adjacent lactate sink, suppressing glycolysis in the epithelium in order to maximize glycolysis in the photoreceptors. Dysregulated metabolism within the RPE has been implicated in the pathogenesis of age-related macular...

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PMID: 38567515
DOI: 10.1042/bsr20231904

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