Article

Photoreceptors have a dual dependency on both aerobic glycolysis and OXPHOS and diverge metabolically from other retinal neurons

2026-03-03

Abstract excerpt

The retina metabolizes glucose into lactate, a hallmark of aerobic glycolysis known as the Warburg effect. Although evidence points to rod photoreceptors as the primary source of aerobic glycolysis, a comparison of the energy metabolism in different retinal neurons has yet to be performed. We combined two-photon fluorescence lifetime imaging of biosensors with pharmacological protocols to analyse metabolic dynamic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a43498b5-441e-5ba2-81b3-8977efcb0b3b
DOI: 10.64898/2026.03.02.709047

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Photoreceptors have a dual dependency on both aerobic glycolysis and OXPHOS and diverge metabolically from other retinal neuronsDOI 10.64898/2026.03.02.709047Read

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activationSemantic proximity Read

Retinal metabolism: Evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycleSemantic proximity Read

Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degenerationSemantic proximity Read

Metabolism and Vascular Retinopathies: Current Perspectives and Future DirectionsSemantic proximity Read

Photoreceptor metabolic reprogramming: current understanding and therapeutic implicationsSemantic proximity Read

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and RepairSemantic proximity Read

Metabolic features of mouse and human retinas: rods vs. cones, macula vs. periphery, retina vs. RPESemantic proximity Read

Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and DegenerationSemantic proximity Read

Metabolism in the Zebrafish RetinaSemantic proximity Read

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod PhotoreceptorsSemantic proximity Read

Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy IntersectionSemantic proximity Read

Metabolic dysfunction promoted by mitochondrial DNA mutation burden drives retinal degenerationSemantic proximity Read