Article

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

2022-10-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local decrease in oxygen availability causing the formation of hypoxic areas affecting the photoreceptor (PR) cells. Here, we addressed the underlying pathological mechanisms of PR degeneration by focusing on energy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86dbb14e-7f0d-570a-813b-06bb1734765e
DOI: 10.21203/rs.3.rs-2080894/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activationDOI 10.21203/rs.3.rs-2080894/v1Read

Photoreceptors have a dual dependency on both aerobic glycolysis and OXPHOS and diverge metabolically from other retinal neuronsSemantic proximity Read

Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degenerationSemantic proximity Read

Retinal metabolism: Evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycleSemantic proximity Read

Metabolism and Vascular Retinopathies: Current Perspectives and Future DirectionsSemantic proximity Read

Chronic Hypoxic Signalling Reprograms Metabolism and Alters Redox and Lipid Homeostasis in Rod PhotoreceptorsSemantic proximity Read

Metabolic dysfunction promoted by mitochondrial DNA mutation burden drives retinal degenerationSemantic proximity Read

Early mitochondrial stress and metabolic imbalance lead to photoreceptor cell death in retinal degenerationSemantic proximity Read

Photoreceptor metabolic reprogramming: current understanding and therapeutic implicationsSemantic proximity Read

Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and DegenerationSemantic proximity Read

Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and RepairSemantic proximity Read

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stressSemantic proximity Read

Metabolic reprogramming of the retinal pigment epithelium by cytokines associated with age-related macular degenerationSemantic proximity Read