Article

Nutrient Microenvironments Reprogram Pigment Epithelium Metabolism and Phenotype

2026-02-13

Abstract excerpt

Induced pluripotent stem cell-derived retinal pigment epithelium (iPSC RPE) has become a widely used model for studying the mechanisms of age-related macular degeneration (AMD). However, the nutrient composition of currently used RPE culture media is highly variable, posing a major challenge to reproducibility in RPE metabolism and phenotype. We systematically investigate how six distinct nutrient microenvironment...

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Literature Corpus work: e1a6a575-784b-5f79-a561-a59b646a9774
DOI: 10.64898/2026.02.11.705448

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