Article

Evidence for a rod-to-cone lactate shuttle in the mammalian retina

2026-08-25

Abstract excerpt

In his seminal 1920s studies, Otto Warburg found the retina to generate large amounts of lactate. However, it was unclear what retinal cells produced lactate and whether it was a metabolic waste product or used further. Here, we show that lactate produced by rod photoreceptors fuels the energy-intensive function and viability of cone photoreceptors. In an initial expression analysis, we found monocarboxylate trans...

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Literature Corpus work: 91feefa6-f471-5195-9976-48b456f34d1c
DOI: 10.64898/2026.08.21.744797

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