Article

Metabolic dysfunction promoted by mitochondrial DNA mutation burden drives retinal degeneration

2025-07-31

Abstract excerpt

Retinal degenerative diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa, and glaucoma, have been linked to mitochondrial dysfunction. However, the impact of mitochondrial DNA (mtDNA) mutation accumulation in the context of these retinopathies has yet to be thoroughly explored. Our previous studies focused on the retinal phenotype observed in the PolgD257A mutator mice (D257A), revealing...

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Literature Corpus work: 92f25292-a664-57fe-bd17-b7195b52c5c4
DOI: 10.1101/2025.07.30.667736

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