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Article

PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration

9 Aug 2024

Abstract excerpt

Age-related macular degeneration (AMD) causes severe blindness in the elderly due to choroidal neovascularization (CNV), which results from the dysfunction of the retinal pigment epithelium (RPE). While normal RPE depends exclusively on mitochondrial oxidative phosphorylation for energy production, the inflammatory conditions associated with metabolic reprogramming of the RPE play a pivotal role in CNV. Although...

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PMID: 39122684
DOI: 10.1038/s41419-024-06968-0

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