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Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration

2 Sept 2024

Abstract excerpt

Subretinal fibrosis permanently impairs the vision of patients with neovascular age-related macular degeneration. Despite emerging evidence revealing the association between disturbed metabolism in retinal pigment epithelium (RPE) and subretinal fibrosis, the underlying mechanism remains unclear. In the present study, single-cell RNA sequencing revealed, prior to subretinal fibrosis, genes in mitochondrial fatty...

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PMID: 39223298
DOI: 10.1038/s42003-024-06773-7

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